However, we deemed it important to point out some difficult andĬonfusing issues in sequence analysis and warn the readers against the most common To duplicate the “click here”-type tutorials, which are available on Importantly, because we cannot claim advanced expertise in this area. In particular, we refrained fromĪny extensive discussion of the statistical basis and algorithmic aspects of sequenceĪnalysis because these can be found in several recent books on computational biology and We attempted to strike a balanceīetween generalities and specifics, aiming to give the reader a clear perspective of theĬomputational approaches used in comparative and functional genomics, rather thanĭiscuss any one of these approaches in great detail. Upon this subject in the previous chapter and further discuss it in Chapter 5). Procedures may result in numerous errors in genome annotation (we have already touched
Some practical experience with their use. These methods are not, in themselves, part of genomics, no reasonable genome analysisĪnd annotation would be possible without understanding how these methods work and having Practical aspects of sequence and, to a lesser degree, structure analysis. This chapter is the longest in the book as it deals with both general principles and Genetic evidence for Near-Eastern origins of European cattle. Troy CS, MacHugh DE, Bailey JF, Magee DA, Loftus RT, Cunningham P, Chamberlain AT,
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